Dr. Zhao is now professor of School of Chemistry & Materials Science. He has engaged in the study of small molecule compound design and synthesis, the activity of anti-tumor as well as Allylation reaction. Zhao has published a series of papers in international academic journals such as Org. Lett., J. Org. Chem., Bioorg. Med. Chem., Eur. J. Med. Chem., Bioorg. Med. Chem. Lett., Eur. J. Org. Chem., Tetrahedron, Tetrahedron Lett., Synthesis, Synlett, and RSC Adv. And he obtained a national patent on an invention in 2013.
Research Interests
Small molecule compound design and synthesis
Study of the activity of anti-tumor
Allylation reaction
Educational Background
MCMP, College of Pharmacy,Purdue University, 2013;
Doctor of Science in medicinal chemistry, School of Pharmacy, Shanghai Jiao Tong University, 2008;
Bachelor in pharmacy, Yanbian University of Pharmaceutical Science, 1998.
Research Projects in Recent Years
1. Jiangsu Natural Science Fund Project (No. BK2012576), 2012-2015.
2. Jiangsu Institutes of Higher Learning Natural Science Research Key Project (No. 12KJA150005), 2012-2015.
3. Jiangsu Institutes of Higher Learning Natural Science Research Project (No. 09KJD150006), 2009-2011.
4. Xuzhou Science and Technology Project (No. XJ09078), 2009-2011.
Selected Publications
1. Zhao Li-Ming, Jin Hai-Shan, Liu Jinzhong, Todd C. Skaar, Joseph Ipe, Lv Wei, David A. Flockhart, Mark Cushman*. (2016). A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β. Bioorg. Med. Chem., 24 (21), 5400-5409.
2. Zhao Li-Ming*, Zhang Ai-Li, Zhang Jie-Huan, Gao Hua-Shuai, Zhou Wei. (2016). Zinc-mediated C-3 α-prenylation of isatins with prenyl bromide: Access to 3-prenyl-3-hydroxy-2-oxindoles and its application. J. Org. Chem., 81 (13), 5487-5494.
3. Zhao Li-Ming,* Cao Feng-Xia, Zhang Jie-Huan, Jeffrey Szwayab, Wang Guangdi*. (2016). One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl) anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities. Bioorg. Med. Chem. Lett., 26 (11), 2691-2694.
4. Jin Hai-Shan, Sun Rui, Zhou Wei, Zhao Li-Ming*. (2016). Diastereoselective synthesis of 3,3-dimethylazetidines via an intramolecular iodinemediated cyclization reaction. RSC Adv., 6 (18), 15035-15038.
5. Zhao Li-Ming*, Zhang Ai-Li, Gao Hua-Shuai, Zhang Jie-Huan. (2015). Synthesis of furo[3,2-c]benzopyrans via an intramolecular [4 + 2] cycloaddition reaction of o-quinonemethides. J. Org. Chem., 80 (20), 10353-10358.
6. Zhao Li-Ming*, Ma Feng-Yan, Jin Hai-Shan, Zheng Shilong, Zhong Qiu, Wang Guangdi*. (2015). Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. Eur. J. Med. Chem., 102, 303-309.
7. Cao Feng-Xia & Zhao Li-Ming*. (2015). Cyclization of 1,4-dihydroxyanthraquinone with α,β-unsaturated aldehyde: a new strategy for the synthesis of cyclopentanoids. Tetrahedron Lett., 56 (21), 2724-2727.
8. Jin Hai-Shan, Zhang Shu-Qing, Sun Rui, Dou Fei, Zhao Li-Ming*. (2014). Introduction of prenyl fragment into chalcones through α-regioselective 1,2-addition in THF. RSC Adv., 4 (42), 21810-21814.
9. Zhao Li-Ming*, Dou Fei, Sun Rui, Zhang Ai-Li. (2014). Regioselective synthesis of substituted tetrahydrofurans through Prins cyclization. Synlett, 25 (10), 1431-1434.
10. Zhao Li-Ming*, Zhang Shu-Qing, Dou Fei, Sun Rui. (2013). Zinc-mediated highly α-regioselective 1,4-addition of chalcones with prenyl bromide in THF. Org. Lett., 15 (20), 5154-5157.
11. Zhao Li-Ming*, Ma Feng-Yan, Jin Hai-Shan, Ma Jiao, Wang Huan, Fu Chuan-Zhao. (2013). Facile installation of a hydroxyalkyl group into hydroxyanthraquinones and aminoanthraquinones through the modified Marschalk reaction. Eur. J. Org. Chem., (31), 7193-7199.
12. Zhao Li-Ming*, Wan Li-Jing, Zhang Shu-Qing, Sun Rui, Ma Feng-Yan. (2013). α-Regioselective construction of gem-bisprenyl structures via zinc-mediated prenylation of esters in THF. Tetrahedron, 69 (37), 7970-7974.
13. Zhao Li-Ming*, Zhang Li-Ming, Ma Feng-Yan, Wang Xiang-Shan, Jin Hai-Shan. (2013). Catalyst-free Mannich reaction of hydroxyanthraquinone: facile access to emodin Mannich bases and anthraoxazines. Tetrahedron Lett., 54 (22), 2802-2805.
14. Zhao Li-Ming*, Zhang Shu-Qing, Jin Hai-Shan, Wan Li-Jing, Dou Fei. (2012). Zinc-mediated highly α-regioselective prenylation of imines with prenyl bromide. Org. Lett., 14 (3), 886-889.
15. Zhao Li-Ming*, Zhang Li-Ming, Liu Jin-Juan, Wan Li-Jing, Chen Yong-Qiang, Zhang Shu-Qing, Yan Zhi-Wei, Jiang Ji-Hong. (2012). Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin. Eur. J. Med. Chem., 47, 255-260.
16. Zhao Li-Ming*, Wan Li-Jing, Jin Hai-Shan, Zhang Shu-Qing. (2012). High regiocontrol in the zinc-mediated crotylation of aldehydes and ketones: a straightforward and facile approach to the linear homoallylic alcohols in DMPU. Eur. J. Org. Chem., (13), 2579-2584.
Honors and Awards
Supervisor of Excellent Undergraduate Thesis, JSNU, 2012
Advanced Individual in “Creating Excellence”, JSNU, 2012
Advanced Worker, JSNU, 2013
Supervisor of Excellent Undergraduate Thesis, JSNU, 2015 / 2016
Contact Information
Email: lmzhao@jsnu.edu.cn