Dr. Shi is now professor of School of Chemistry & Materials Science. She has engaged in the study of Tandem asymmetric reaction of organic molecular catalysis as well as Asymmetric catalysis and Synthesis. Shi has published over 80 papers in international academic journals such as Angew. Chem. Int. Ed., Chem. Commun., Org. Lett., Chem. Eur. J., Adv. Synth. Catal., and J. Org. Chem.. And she holds 4 patents.
Research Interests
Tandem asymmetric reaction of organic molecular catalysis
Asymmetric catalysis and Synthesis
Educational Background
Visiting Scholar, Nanyang Technological University, Singapore, 2012-2013;
Doctor of Science in Chemicobiology, Soochow University and University of Science and Technology of China, 2010-2013;
Master of Science in Organic Chemistry, XZNU (now JSNU), 2001-2004;
Bachelor in Chemical Education, XZNU (now JSNU), 1994-1998.
Research Projects in Recent Years
1. National Natural Science Fund Project (No. 21772069, ¥660,000): Tandem asymmetric reaction with the Involvement of Indole mother nucleus. 2018-2021.
2. National Natural Science Fund Project (No. 21372002, ¥800,000): The Design of Catalytic asymmetrymulticomponent reaction. 2014-2017.
3. Jiangsu Department of Science and Technology Project (No. BK20160003, ¥1,000,000): Tandem asymmetric reaction with the Involvement of Indole mother nucleus. 2016-2019.
4. National Natural Science Fund Project (No. 21002083, ¥190,000), 2011-2013.
Selected Publications
1. Zhang Hong-Hao, Wang Cong-Shuai, Li Can, Mei Guang-Jian, Li Yuxue*, Shi Feng*. (2017). Design and Enantioselective Construction of Axially Chiral Naphthyl-Indole Skeletons.Angewandte Chemie, International Edition, 56(1), 116-121.
2. Jiang Fei, Zhao Dan, Yang Xue, Yuan Fu-Ru, Mei Guang-Jian, Shi Feng*. (2017). Catalyst-Controlled Chemoselective and Enantioselective Reactions of Tryptophols with Isatin-Derived Imines. ACS Catalysis, 7(10), 6984-6989.
3. Zhu Zi-Qi, Shen Yang, Liu Jin-Xi, Tao Ji-Yu, Shi Feng*. (2017). Enantioselective Direct a-Arylation of Pyrazol-5-ones with 2-Indolylmethanols via Organo-Metal Cooperative Catalysis. Organic Letters, 19(7), 1542-1545.
4. Mei Guang-Jian*, Bian Chen-Yu, Li Guo-Hao, Xu Shao-Li, Zheng Wen-Qin, Shi Feng*. (2017). Catalytic Asymmetric Construction of the Tryptanthrin Skeleton via an Enantioselective Decarboxylative [4 + 2] Cyclization. Organic Letters, 19(12), 3219-3222.
5. Mei Guang-Jian, Zhu Zi-Qi, Zhao Jia-Jia, Bian Chen-Yu, Chen Jie, Chen Ruo-Wei, Shi Feng*. (2017). Bronsted acid-catalyzed stereoselective [4+3] cycloadditions of ortho-hydroxybenzyl alcohols with N,N'-cyclic azomethine imines. Chemical Communications, 53(18), 2768-2771.
6. Mei Guang-Jian*, Li Dan, Zhou Gui-Xiang, Shi Qian, Cao Zheng, Shi Feng*. (2017). A catalytic asymmetric construction of a tetrahydroquinoline-based spirooxindole framework via a diastereoand enantioselective decarboxylative [4+2] cycloaddition. Chemical Communications, 53(72), 10030-10033.
7. Sun Xiao-Xue, Li Can, He Ying-Ying, Zhu Zi-Qi, Mei Guang-Jian, Shi Feng*. (2017). Catalytic Asymmetric [3+3] Cycloaddition of Azomethine Ylides with C3-Substituted 2-Indolylmethanols. Advanced Synthesis & Catalysis, 359(15), 2660-2670.
8. Jiang Xiao-Li, Liu Si-Jia, Gu Yu-Qi, Mei Guang-Jian*, Shi Feng*. (2017). Catalytic Asymmetric [4+1] Cyclization of ortho-Quinone Methides with 3-Chlorooxindoles. Advanced Synthesis & Catalysis, 359(19), 3341-3346.
9. Mei Guang-Jian & Shi Feng*. (2017). Indolylmethanols as Reactants in Catalytic Asymmetric Reactions. Journal of Organic Chemistry, 82(15), 7695-7707.
10. Xu Meng-Meng, Wang Hai-Qing, Wan Ying, Wang Shu-Liang, Shi Feng*. (2017). Enantioselective Construction of Cyclopenta[b]indole Scaffolds via the Catalytic Asymmetric [3 + 2] Cycloaddition of 2-Indolylmethanols with p-Hydroxystyrenes. Journal of Organic Chemistry, 82(19), 10226-10233.
11. He Ying-Ying, Sun Xiao-Xue, Li Guo-Hao, Mei Guang-Jian*, Shi Feng*. (2017). Substrate-Controlled Regioselective Arylations of 2-Indolylmethanols with Indoles: Synthesis of Bis(indolyl)methane and 3,3'-Bisindole Derivatives. Journal of Organic Chemistry, 82(5), 2462-2471.
12. Xu Meng-Meng, Wang Hai-Qing, Wan Ying, He Guofeng, Yan Jingjing, Zhang Shu*, Wang Shu-Liang, Shi Feng*. (2017). Catalytic asymmetric substitution of ortho-hydroxybenzyl alcohols with tetronic acid-derived enamines: enantioselective synthesis of tetronic acid-derived diarylmethanes. Organic Chemistry Frontiers, 4(3), 358-368.
13. Zhu Zi-Qi, Yin Lei, Wang Yang, Shen Yang, Li Can, Mei Guang-Jian*, Shi Feng*. (2017). Diastereo- and enantioselective construction ofbiologically important pyrrolo[1,2-a]indolescaffolds via catalytic asymmetric[3 +2]cyclodimerizations of 3-alkyl-2-vinylindoles. Organic Chemistry Frontiers, 4(1), 57-68.
14. Wang Yue-Ming, Zhang Hong-Hao, Li Can, Fan Tao, Shi Feng*. (2016). Catalytic asymmetric chemoselective 1,3-dipolar cycloadditions of an azomethine ylide with isatin-derivedimines: diastereo- and enantioselective construction of a spiro[imidazolidine-2,3'-oxindole] framework. Chemical Communications, 52(9), 1804-1807.
15. Sun Xiao-Xue, Zhang Hong-Hao, Li Guo-Hao, Meng Li, Shi Feng*. (2016). Diastereo- and enantioselective construction of an indole-based 2,3-dihydrobenzofuran scaffold via catalyticasymmetric [3+2] cyclizations of quinone monoimides with 3-vinylindoles. Chemical Communications, 52(14), 2968-2971.
16. Zhao Jia-Jia, Tang Man, Zhang Hong-Hao, Xu Meng-Meng, Shi Feng*. (2016). Bronsted acid-catalyzed chemodivergent reactions of ortho-mercaptobenzyl alcohols with 3-alkyl-2-vinylindoles and styrenes: [5+2] cyclization versus hydroxysulfenylation. Chemical Communications, 52(35), 5953-5956.
17. Sun Xiao-Xue, Zhang Hong-Hao, Li Guo-Hao, He Ying-Ying, Shi Feng*. (2016). Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2-Indolylmethanols as 3 C Building Blocks. Chemistry - A European Journal, 22(49), 17526-17532.
18. Zhang Hong-Hao, Zhu Zi-Qi, Fan Tao, Liang Jing, Shi Feng*. (2016). Intermediate-Dependent Unusual [4+3], [3+2] and Cascade Reactions of 3-Indolylmethanols: Controllable Chemodivergent and Stereoselective Synthesis of Diverse Indole Derivatives. Advanced Synthesis & Catalysis, 358(8), 1259-1288.
19. Zhu Zi-Qi, Shen Yang, Sun Xiao-Xue, Tao Ji-Yu, Liu Jin-Xi, Shi Feng*. (2016). Catalytic Asymmetric [3+2] Cycloadditions of C-3 Unsubstituted 2-Indolylmethanols: Regio-, Diastereo- and Enantioselective Construction of the Cyclopenta[b]indole Framework. Advanced Synthesis & Catalysis, 358(23), 3797-3808.
20. Zhou Lu-Jia, Zhang Yu-Chen, Jiang Fei, He Guofeng, Yan Jingjing, Lu Han*, Zhang Shu*, Shi Feng*. (2016). Enantioselective Construction of Cyclic Enaminone-Based 3-Substituted 3-Amino-2-oxindole Scaffolds via Catalytic Asymmetric Additions of Isatin-Derived Imines. Advanced Synthesis & Catalysis, 358(19), 3069-3083.
21. Fan Tao, Zhang Hong-Hao, Li Can, Shen Yang, Shi Feng*. (2016). The Application of N-Protected 3-Vinylindoles in Chiral Phosphoric Acid-Catalyzed [3+2] Cyclization with 3-Indolylmethanols: Monoactivation of the Catalyst to Vinyliminium. Advanced Synthesis & Catalysis, 358(12), 2017-2031.
22. Yin Lei, Wang Yang, Sun Meng, Shi Feng*. (2016). Bronsted Acid-Catalyzed [3+2] Cyclodimerization of 3-Alkyl- 2-vinylindoles Leading to the Diastereoselective Construction of a Pyrroloindole Framework. Advanced Synthesis & Catalysis, 358(7), 1093-1102.
23. Wu Jia-Le, Du Bai-Xiang, Zhang Yu-Chen, He Ying-Ying, Wang Jing-Yi, Wu Ping, Shi Feng*. (2016). Diastereo- and Enantioselective Construction of Dihydroisocoumarin-Based Spirooxindole Frameworks via Organocatalytic Tandem Reactions. Advanced Synthesis & Catalysis, 358(17), 2777-2790.
24. Zhang Yu-Chen, Zhu Qiu-Ning, Yang Xue, Zhou Lu-Jia, Shi Feng*. (2016). Merging Chiral Bronsted Acid/Base Catalysis: An Enantioselective [4 + 2] Cycloaddition of o-Hydroxystyrenes with Azlactones. Journal of Organic Chemistry, 81(4), 1681-1688.
25. Wang Cong-Shuai, Fan Tao, Zhang Hong-Hao, Li Can, Shen Yang, Mei Guang-Jian*, Shi Feng*. (2016). Gallium Bromide-Promoted Dearomative Indole Insertion in 3-Indolylmethanols: Chemoselective and (Z/E)-Selective Synthesis of 3,3'-Bisindole Derivatives. Journal of Organic Chemistry, 81(23), 11734-11742.
26. Zhu Qiu-Ning, Zhang Yu-Chen, Xu Meng-Meng, Sun Xiao-Xue, Yang Xue, Shi Feng*. (2016). Enantioselective Construction of Tetrahydroquinolin-5-one-Based Spirooxindole Scaffold via anOrganocatalytic Asymmetric Multicomponent [3 + 3] Cyclization. Journal of Organic Chemistry, 81(17), 7898-7907.
27. Yang Xue, Zhang Yu-Chen, Zhu Qiu-Ning, Tu Man-Su*, Shi Feng*. (2016). Diastereo- and Enantioselective Construction of the Hexahydrocoumarin Scaffold via an Organocatalytic Asymmetric [3 + 3] Cyclization. Journal of Organic Chemistry, 81(12), 5056-5065.
28. Dai Wei, Jiang Xiao-Li, Tao Ji-Yu, Shi Feng*. (2016). Application of 3-Methyl-2-vinylindoles in Catalytic Asymmetric Povarov Reaction: Diastereo- and Enantioselective Synthesis of Indole-Derived Tetrahydroquinolines. Journal of Organic Chemistry, 81(1), 185-192.
29. Zhao Jia-Jia, Sun Si-Bing, He Sai-Huan, Wu Qiong, Shi Feng*. (2015). Catalytic Asymmetric Inverse-Electron-Demand Oxa-Diels-Alder Reaction of In Situ Generated ortho-Quinone Methides with 3-Methyl-2-Vinylindoles. Angewandte Chemie, International Edition, 54(18), 5460-5464.
30. Cong-Shuai Wang, Ren-Yi Zhu, Yu-Chen Zhang and Feng Shi*. (2015). Catalytic Chemoselective [3+3] Cycloadditions of Azomethine Ylides with Quinone Monoimides Leading to the Construction of A Dihydrobenzoxazine Scaffold. Chemical Communications, 51, 11798-11801.
31. Jia-Jia Zhao, Yu-Chen Zhang, Meng-Meng Xu, Man Tang, and Feng Shi*. (2015). Catalytic Chemo-, E/Z-, and Enantioselective Cyclizations of o-Hydroxybenzyl Alcohols with Dimedone-Derived Enaminones. Journal of OOrganic Chemistry, 80, 10016−10024.
32. Wei Dai, Xiao-Li Jiang, Qiong Wu, Feng Shi*, Shu-Jiang Tu. (2015). Diastereo- and Enantioselective Construction of 3,3’-Pyrrolidinyldispirooxindole Framework via Catalytic Asymmetric 1,3-Dipolar Cycloadditions. Journal of Organic Chemistry, 80, 5737-5744.
33. Wang Yang, Tu Man-Su, Yin Lei, Sun Meng, Shi Feng*. (2015). Bronsted Acid Catalyzed Asymmetric Diels-Alder Reactions: Stereoselective Construction of Spiro[tetrahydrocarbazole-3,3'-oxindole] Framework. Journal of Organic Chemistry, 80(6), 3223-3232.
34. Li Xin, Tan Wei, Gong Yu-Xin, Shi Feng*. (2015). Catalyst-Controlled Chemoselective Reaction of 3-Indolylmethanols with Cyclic Enaminones Leading to C2-Functionalized Indoles. Journal of Organic Chemistry, 80(3), 1841-1848.
35. Wang Cong-Shuai, Zhu Ren-Yi, Zheng Jian, Shi Feng*, Tu Shu-Jiang. (2015). Enantioselective Construction of Spiro[indoline-3,2'-pyrrole] Framework via Catalytic Asymmetric 1,3-DipolarCycloadditions Using Allenes as Equivalents of Alkynes. Journal of Organic Chemistry, 80(1), 512-520.
36. Shi Feng*, Zhang Hong-Hao, Sun Xiao-Xue, Liang Jing, Fan Tao, Tu Shu-Jiang. (2015). Organocatalytic Asymmetric Cascade Reactions of 7-Vinylindoles: Diastereo- and Enantioselective Synthesis of C7-Functionalized Indoles. Chemistry - A European Journal, 21(8), 3465-3471.
37. Jiang Fei, Zhang Yu-Chen, Sun Si-Bing, Zhou Lu-Jia, Shi Feng*. (2015). Organocatalytic Reactions of Indoles with Quinone Imine Ketals: An Alternative Metal-Free Approach to Bioactive meta-Indolylanilines. Advanced Synthesis & Catalysis, 357, 1283-1292.
38. Yang Wang, Meng Sun, Lei Yin and Feng Shi*. (2015). Catalytic Enantioselective Arylative Dearomatization of 3-Methyl-2-vinylindoles Enabled by Reactivity Switch. Advanced Synthesis & Catalysis, 357, 4031-4040.
39. Sun Xiao-Xue, Du Bai-Xiang, Zhang Hong-Hao, Ji Lei, Shi Feng*. (2015). Catalytic Asymmetric Arylation of 3-Indolylmethanols: Enantioselective Synthesis of 3,3'-Bis(indolyl)oxindoles with High Atom Economy. ChemCatChem, 7(7), 1211-1221.
40. Zhang Yu-Chen, Zhao Jia-Jia, Jiang Fei, Sun Si-Bing, Shi Feng*. (2014). Organocatalytic Asymmetric Arylative Dearomatization of 2,3-Disubstituted Indoles Enabled by Tandem Reactions. Angewandte Chemie, International Edition, 53(50), 13912-13915.
41. Tan Wei, Li Xin, Gong Yu-Xin, Ge Meng-Di, Shi Feng*. (2014). Highly diastereo- and enantioselective construction of a spiro[cyclopenta[b]indole-1,3'-oxindole] scaffold via catalytic asymmetric formal [3+2] cycloadditions. Chemical Communications, 50(100), 15901-15904.
42. Liu Yan, Zhang Hong-Hao, Zhang Yu-Chen, Jiang Yan, Shi Feng*, Tu Shu-Jiang. (2014). Organocatalytic enantioselective and (Z)-selective allylation of 3-indolylmethanol via hydrogen-bond activation. Chemical Communications, 50(81), 12054-12057.
43. Wang Yang, Shi Feng*, Yao Xi-Xi, Sun Meng, Dong Liang, Tu Shu-Jiang. (2014). Catalytic Asymmetric Construction of 3,3'-Spirooxindoles Fused with Seven-Membered Rings by Enantioselective Tandem Reactions. Chemistry - A European Journal, 20(46), 15047-15052.
44. Shi Feng*, Zhu Ren-Yi, Dai Wei, Wang Cong-Shuai, Tu Shu-Jiang*. (2014). Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework. Chemistry - A European Journal, 20(9), 2597-2604.
45. Dai Wei, Lu Han, Li Xin, Shi Feng*, Tu Shu-Jiang. (2014). Diastereo- and enantioselective construction of a bispirooxindole scaffold containing a tetrahydro-b-carboline moiety through an organocatalytic asymmetric cascade reaction. Chemistry - A European Journal, 20(36), 11382-11389.
46. Wang Yang, Tu Man-Su, Shi Feng*, Tu Shu-Jiang. (2014). Enantioselective construction of the biologically significant dibenzo[1,4]diazepine scaffold via organocatalytic asymmetric three-component reactions. Advanced Synthesis & Catalysis, 356(9), 2009-2019.
47. Zhou Lu-Jia, Zhang Yu-Chen, Zhao Jia-Jia, Shi Feng*, Tu Shu-Jiang. (2014). Organocatalytic Arylation of 3-Indolylmethanols via Chemo- and Regiospecific C6-Functionalization of Indoles. Journal of Organic Chemistry, 79(21), 10390-10398.
48. Zhu Ren-Yi, Wang Cong-Shuai, Zheng Jian, Shi Feng*, Tu Shu-Jiang. (2014). Organocatalytic Asymmetric Inverse-Electron-Demand 1,3-Dipolar Cycloaddition of N,N'-Cyclic Azomethine Imines. Journal of Organic Chemistry, 79(19), 9305-9312.
49. Zhang Hong-Hao, Wang Yue-Ming, Xie Yuan-Wei, Zhu Zi-Qi, Shi Feng*, Tu Shu-Jiang. (2014). Organocatalytic Chemo-, (E/Z)- and Enantioselective Formal Alkenylation of Indole-Derived Hydroxylactams Using o-Hydroxystyrenes as a Source of Alkenyl Group. Journal of Organic Chemistry, 79(15), 7141-7151.
50. Zhang Yu-Chen, Jiang Fei, Wang Shu-Liang*, Shi Feng*, Tu Shu-Jiang. (2014). Organocatalytic Chemo- and Regioselective Oxyarylation of Styrenes via a Cascade Reaction: Remote Activation of Hydroxyl Groups. Journal of Organic Chemistry, 79(13), 6143-6152.
51. Tan Wei, Du Bai-Xiang, Li Xin, Zhu Xu, Shi Feng*, Tu Shu-Jiang. (2014). Catalytic Asymmetric Aza-ene Reaction of 3-Indolylmethanols with Cyclic Enaminones: Enantioselective Approach to C3-Functionalized Indoles. Journal of Organic Chemistry, 79(10), 4635-4643.
52. Shi Feng*, Xing Gui-Juan, Zhu Ren-Yi, Tan Wei, Tu Shujiang*. (2013). A Catalytic Asymmetric Isatin-Involved Povarov Reaction: Diastereo- and Enantioselective Construction of Spiro[indolin-3,2'-quinoline] Scaffold. Organic Letters, 15(1), 128-131.
53. Shi Feng*, Tan Wei, Zhang Hong-Hao, Li Mei, Ye Qin, Ma Guan-Hua, Tu Shu-Jiang*, Li Guigen. (2013). Asymmetric Organocatalytic Tandem Cyclization/Transfer Hydrogenation: A Synthetic Strategy for Enantioenriched Nitrogen Heterocycles. Advanced Synthesis & Catalysis, 355(18), 3715-3726.
54. Shi Feng*, Zhu Ren-Yi, Liang Xia, Tu Shu-Jiang*. (2013). Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2'-pyrrole] Derivatives. Advanced Synthesis & Catalysis, 355(11-12), 2447-2458.
55. Shi Feng*, Tan Wei, Zhu Ren-Yi, Xing Gui-Juan, Tu Shu-Jiang*. (2013). Catalytic Asymmetric Five-Component Tandem Reaction: Diastereoselective and Enantioselective Synthesis of Densely Functionalized Tetrahydropyridines with Biological Importance. Advanced Synthesis & Catalysis, 355(8), 1605-1622.
Honors and Awards
International academic award, The 11th Asian Core Program (ACP) Lectureship Award, 2016
International academic award, Thieme Chemistry Journal Award, 2014
Second Prize of MOE S&T Progress, 2011
Third Prize of Xuzhou Outstanding Natural Science Academic Paper Award, 2010
Second Prize of Xuzhou Outstanding Natural Science Academic Paper Award, 2008
Second Prize of S&T Progress, CPCIF, 2008
Contact Information
Email: fshi@jsnu.edu.cn