Dr. Hongwei Gai has been a professor of School of Chemistry and Materials Science at Jiangsu Normal University since Dec. 2011. He earned his doctoral degree in analytical chemistry at Chinese Science of Academy, Dalian Institute of Chemical Physics in 2005. After he did his postdoctoral work in Health Science Center at Texas University in San Antonio, Dr. Gai joined Biomedical Engineering Center at Hunan University as an appointed professor in Dec. 2006. Dr. Gai became a full professor in Aug. 2009 and then in School of Biology after Jan. 2010. Dr. Gai’s research focuses on single molecule fluorescence imaging and the application in chemistry and biology. Dr. Gai has published over 30 scientific papers mostly in journals like Anal Chem, Lab Chip, Chem Commun, Angew Chem Int Ed, and he holds five patents. Dr. Gai received Young Scholar and General Project from National Natural Science Foundation.
Research Interests
Bio-analytical chemistry
Biochemical analysis and sensing
Laboratory for Microfluidic chip
Detection of single particle and single molecule
Educational Background
Post Doctorate, UT Health San Antonio, 2005;
PhD in Analysis Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 2000;
MA, School of Chemical Engineering, Dalian University of Technology, 1997;
BA, School of Chemical Engineering, Xi’an Jiaotong University, 1993.
Research Projects in Recent Years
1. National Natural Science Fund Project (No. 21575053): Study on HR Light Stream Control and Display Micro Imaging Technology and Application. 2016-2019.
2. National Natural Science Fund Project (No. 21075033): Single Molecule Distant Field Three Dimension Imaging Technology. 2011-2013.
3. National Natural Science Fund Project (No. 20705007): Microarray Chip. 2008-2010.
4. Hunan Department of Science and Technology Project (No. 2008WK3004): Study on the Marrow Micrometastasis of Lung Cancer Based on Single Molecule Microarray Chip. 2008-2009.
5. Hunan Department of Science and Technology Project (No. 2011TT2026): Non-les Micro Imaging System on Micro Chip. 2012.
Selected Publications
1. Suli Dong, Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Aiye Liang, Hongwei Gai*. (2017). Sensing active heparin by counting aggregated quantum dots at single-particle level. ACS Sensors, 2, 80-86.
2. Qiangquan Zhang, Hanlin Li, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Hongwei Gai*. (2016). A self-driven miniaturized liquid fuel cell. Chemical Communications, 52, 12068-12071.
3. Qingquan Zhang, Meng Xu, Xiaojun Liu, Wenfeng Zhao, Chenghua Zong, Yang Yu, Qi Wang*, Hongwei Gai*. (2016). Fabrication of Janus droplets by evaporation driven liquid-liquid phase separation. Chemical Communications, 52, 5015-5018.
4. Xiaojun Liu, Zhangjian Wu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Hongwei Gai*. (2016). Single Gold Nanoparticle-Based Colorimetric Detection of Picomolar Mercury Ion with Dark-Field Microscopy. Analytical Chemistry, 88, 2119-2124.
5. Wenfeng Zhao*, Wei Jia, Mimi Sun, Xiaojun Liu, Qingquan Zhang, Chenghua Zong, Hongwei Gai*. (2016). Colorimetric detection of Cu 2+ by surface coordination complexes of polyethyleneimine-capped Au nanoparticles, Sensors and Actuators: B. Chemical, 223, 411-416.
6. Xiaojun Liu, Yawei Wang, Yang Tu, Ziqi Zhu, Xiaogang Li, Qingquan Zhang, Wenfeng Zhao, Yuling Li, Hongwei Gai*. (2015). A rapid and simple approach for glycoform analysis. Analytica Chimica Acta, 865, 71-75.
7. Xingbo Shi, Suli Dong, Minmin Li, Xiaojun Liu, Qingquan Zhang, Wenfeng Zhao, Chenghua Zong, Yewang Zhang, Hongwei Gai*. (2015). Counting quantum dot aggregates for the detection of biotinylated proteins. Chemical Communications, 51, 2353-2356.
8. Xingbo Shi, Minmin Li, Wenfeng Zhao, Aiye Liang , Xiaojun Liu, Hongwei Gai*. (2015). Spectral imaging superlocalization microscopy for quantum dots, Sensors and Actuators: B. Chemical, 207, 308-312.
9. Wenfeng Zhao, Suli Dong, Lichun Sun, Qi Wang*, Hongwei Gai*. (2014). Investigating the Photostability of Quantum Dots at the Single-MoleculeLevel. Chemistry-An Asian Journal, 9, 3542-3548.
10. Qingquan Zhang, Xiaojun Liu, Dayu Liu, Hongwei Gai*. (2014). Ultra small droplet generation via volatile component evaporation. Lab on a Chip, 14(8), 1395 - 1400.
11. Xiaojun Liu, Qingquan Zhang, Yang Tu, Hongwei Gai*. (2013). Single Gold Nanoparticle Localized Surface Plasmon Resonance Spectral Imaging for Quantifying Binding Constant of Carbohydrate–Protein Interaction. Analytical Chemistry, 85, 11851–11857.
12. Xingbo Shi, Yang Tu, Xiaojun Liu, Edward S Yeung, Hongwei Gai*. (2013). Photobleaching of Quantum Dots by Non-resonant Light. Physical Chemistry Chemical Physics, 15, 3130-3132.
13. Xiaojun Liu, Hui Wang, Aiye Liang, Yuling Li, Hongwei Gai*, Bingcheng Lin*. (2012). Determination of binding constants between 1 one protein and multiple carbohydrates by affinity chromatography on a microchip. Journal of Chromatography A, 1270,340-343.
14. Xingbo Shi, Zhongqiu Xie, Yuehong Song, Yongjun Tan, Edward S. Yeung, Hongwei Gai*. (2012). Super-Localization Spectral Imaging Microscopy of Multi-color Quantum Dot Complex. Analytical Chemistry, 84(3), 1504-1509.
Honors and Awards
Youth Chemistry Award, Hunan Society of Chemistry and Chemical Industry, 2010
Second Prize, Dalian Science and Technology Reward, 2011
Contact Information
Email: gai@jsnu.edu.cn